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Application of Inductive Logic Programming to Discover Rules Governing the
Three-Dimensional Topology of Protein Structure
M. Turcotte,
S.H. Muggleton,
and M.J.E. Sternberg.
In D. Page, editor, Proceedings of the 8th International Conference on
Inductive Logic Programming, volume 1446 of Lecture Notes in
Artificial Intelligence, pages 53--64. Springer-Verlag, 1998. More behind this link.
Abstract
Inductive Logic Programming (ILP) has been applied to discover rules governing
the three-dimensional topology of protein structure. The data-set unifies two
sources of information; SCOP and PROMOTIF. Cross-validation results for
experiments using two background knowledge sets, global (attribute-valued)
and constitutional (relational), are presented. The application makes use of
a new feature of Progol4.4 for numeric parameter estimation. At this early
stage of development, the rules produced can only be applied to proteins for
which the secondary structure is known. However, since the rules are
insightful, they should prove to be helpful in assisting the development of
taxonomic schemes. The application of ILP to fold recognition represents a
novel and promising approach to this problem.
BibTeX entry.
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S H Muggleton,
stephen@cs.york.ac.uk. Last modified on Wednesday 9 April 2003 at 18:31. © 2003 ILPnet2