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Knowledge discovery in biological and chemical domains
S. Muggleton.
In H. Motoda, editor, Proceedings of the first Conference on Discovery
Science, Berlin, 1998. More behind this link.. Springer-Verlag.
Abstract of keynote talk
Abstract
This talk will review the results of the last few years' academic pilot studies
involving the application of ILP to the prediction of protein secondary
structure, mutagenicity, structure activity , pharmacophore discovery and
protein fold analysis. While predictive accuracy is the central performance
measure of data analytical techniques which generate procedural knowledge
(neural nets, decision trees, etc.), the performance of an ILP system is
determined both by accuracy and degree of stereo-chemical insight provided.
ILP hypotheses can be easily stated in English and exemplified
diagrammatically. This allows cross-checking with the relevant biological and
chemical literature. Most importantly it allows for expert involvement in
human background knowledge refinement and for final dissemination of
discoveries to the wider scientific community. In several of the comparative
trials presented ILP systems provided significant chemical and biological
insights where other data analysis techniques did not. In his statement
of the importance of this line of research to the Royal Society Sternberg
emphasised the aspect of joint human-computer collaboration in scientific
discoveries. Science is an activity of human societies. It is our belief that
computer-based scientific discovery must support strong integration into
existing the social environment of human scientific communities. The
discovered knowledge must add to and build on existing science. The author
believes that the ability to incorporate background knowledge and re-use
learned knowledge together with the comprehensibility of the hypotheses, have
marked out ILP as a particularly effective approach for scientific knowledge
discovery.
BibTeX entry.
Other publications
S H Muggleton,
stephen@cs.york.ac.uk. Last modified on Wednesday 9 April 2003 at 18:31. © 2003 ILPnet2