Suppose you want to form a layout something like this:
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You should be able to visualise this as consisting of three components stacked into a vertical box. The top one is a horizontal box of buttons, and the bottom one is the status line. The middle component is a horizontal box of two components, the left one being a vertical box of tools. Here is a program that's puts all this together, still using just buttons (a couple of them are increased in size, though).
This is rough and ready. To fine tune box layouts, use a combination of library and tutorial documentation, e.g.: