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Inferring the function of genes from synthetic lethal mutations

Oliver Ray, Chris Bryant, Inferring the function of genes from synthetic lethal mutations. 2nd International Conference on Complex, Intelligent and Software Intensive Systems (from 1st International Workshop on Intelligent Informatics in Biology and Medicine), pp. 667–671. February 2008. PDF, 75 Kbytes.


Techniques for detecting synthetic lethal mutations in double gene deletion experiments are emerging as powerful tool for analysing genes in parallel or overlapping pathways with a shared function. This paper introduces a logic-based approach that uses synthetic lethal mutations for mapping genes of unknown function to enzymes in a known metabolic network. We show how such mappings can be automatically computed by a logical learning system called eXtended Hybrid Abductive Inductive Learning (XHAIL).

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