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Evolution of the protein repertoire

Chothia, C., Gough, J., Vogel, C., Teichmann, S. A., Evolution of the protein repertoire. Science, 300 (5626), pp. 1701–1703. June 2003. No electronic version available.


Most proteins have been formed by gene duplication, recombination, and divergence. Proteins of known structure can be matched to about 50% of genome sequences, and these data provide a quantitative description and can suggest hypotheses about the origins of these processes.

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